Epigenetic therapy in allogeneic hematopoietic stem cell transplantation

Epigenetic therapy in allogeneic hematopoietic stem cell transplantation

DNA methylation and other epigenetic phenomena appear to be relevant in the pathogenesis of several malignant disorders. DNA methyltransferases add methyl groups to cytosine-phosphate-guanine (CpG) islandsleading to gene promoter silencing. The DNA methyltransferases inhibitors azacitidine and decit...

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Bibliographic Details
Main Authors: Qaiser Bashir, Basem Magdy William, Guillermo Garcia-Manero, Marcos de Lima
Format: Article
Language:English
Published: Elsevier 2013-01-01
Series:Revista Brasileira de Hematologia e Hemoterapia
Subjects:
Hematopoietic stem cell transplantation
DNA methyltransferase
Leukemia, myeloid
Epigenesis, genetic
Azacitidine
Immunologic factors
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842013000200015

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-84842013000200015

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