Coordination of Engineered Factors with TET1/2 Promotes Early-Stage Epigenetic Modification during Somatic Cell Reprogramming

Coordination of Engineered Factors with TET1/2 Promotes Early-Stage Epigenetic Modification during Somatic Cell Reprogramming

Somatic cell reprogramming toward induced pluripotent stem cells (iPSCs) holds great promise in future regenerative medicine. However, the reprogramming process mediated by the traditional defined factors (OSMK) is slow and extremely inefficient. Here, we develop a combination of modified reprogramm...

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Bibliographic Details
Main Authors: Gengzhen Zhu, Yujing Li, Fei Zhu, Tao Wang, Wensong Jin, Wei Mu, Wei Lin, Weiqi Tan, Wenqi Li, R. Craig Street, Siying Peng, Jian Zhang, Yue Feng, Stephen T. Warren, Qinmiao Sun, Peng Jin, Dahua Chen
Format: Article
Language:English
Published: Elsevier 2014-03-01
Series:Stem Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2213671114000290

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http://www.sciencedirect.com/science/article/pii/S2213671114000290

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