Notoginsenoside R1 activates the NAMPT-NAD+-SIRT1 cascade to promote postischemic angiogenesis by modulating Notch signaling

Notoginsenoside R1 activates the NAMPT-NAD+-SIRT1 cascade to promote postischemic angiogenesis by modulating Notch signaling

Nicotinamide phosphoribosyltransferase (NAMPT) maintains mitochondrial function and protects against cerebral ischemic injury by improving energy metabolism. Notoginsenoside R1 (R1), a unique constituent of Panax notoginseng, has been shown to promote the proliferation and tube formation of human um...

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Bibliographic Details
Main Authors: Ting Zhu, Wei-jie Xie, Lei Wang, Xin-biao Jin, Xiang-bao Meng, Gui-bo Sun, Xiao-bo Sun
Format: Article
Language:English
Published: Elsevier 2021-08-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Ischemic stroke
R1
Neurorestoration
Angiogenesis
Energy metabolism
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332221004753

Internet

http://www.sciencedirect.com/science/article/pii/S0753332221004753

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