Protein Phosphatase 4 and Smek Complex Negatively Regulate Par3 and Promote Neuronal Differentiation of Neural Stem/Progenitor Cells

Neural progenitor cells (NPCs) are multipotent cells that can self-renew and differentiate into neurons and glial cells. However, mechanisms that control their fate decisions are poorly understood. Here, we show that Smek1, a regulatory subunit of the serine/threonine protein phosphatase PP4, promo...

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Bibliographic Details
Main Authors: Jungmook Lyu, Hee-Ryang Kim, Vicky Yamamoto, Si Ho Choi, Zong Wei, Choun-Ki Joo, Wange Lu
Format: Article
Language:English
Published: Elsevier 2013-11-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124713005573