Phosphonylated Acyclic Guanosine Analogues with the 1,2,3-Triazole Linker

Phosphonylated Acyclic Guanosine Analogues with the 1,2,3-Triazole Linker

A novel series of {4-[(2-amino-6-chloro-9H-purin-9-yl)methyl]-1H-1,2,3-triazol-1-yl}alkylphosphonates and {4-[(2-amino-6-oxo-1,6-dihydro-9H-purin-9-yl)methyl]-1H-1,2,3-triazol-1-yl}alkylphosphonates as acyclic analogues of guanosine were synthesized and assessed for antiviral activity against a broa...

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Bibliographic Details
Main Authors: Iwona E. Głowacka, Graciela Andrei, Dominique Schols, Robert Snoeck, Dorota G. Piotrowska
Format: Article
Language:English
Published: MDPI AG 2015-10-01
Series:Molecules
Subjects:
azidophosphonates
acyclonucleotides
1,2,3-triazoles
cycloaddition
antiviral
cytostatic
Online Access:http://www.mdpi.com/1420-3049/20/10/18789

Internet

http://www.mdpi.com/1420-3049/20/10/18789

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