Combination of STING Pathway Agonist With Saponin Is an Effective Adjuvant in Immunosenescent Mice

Combination of STING Pathway Agonist With Saponin Is an Effective Adjuvant in Immunosenescent Mice

There is an urgent need to improve protective responses to influenza vaccination in the elderly population, which is at especially high risk for adverse outcomes from influenza infection. Currently available inactivated vaccines provide limited protection, even when a 4-fold higher dose of the vacci...

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Bibliographic Details
Main Authors: Elena V. Vassilieva, Dahnide W. Taylor, Richard W. Compans
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Immunology
Subjects:
aged mice
influenza vaccine
adjuvant
cGAMP
saponin
Online Access:https://www.frontiersin.org/article/10.3389/fimmu.2019.03006/full

Internet

https://www.frontiersin.org/article/10.3389/fimmu.2019.03006/full

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