Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis

Pask integrates hormonal signaling with histone modification via Wdr5 phosphorylation to drive myogenesis

PAS domain containing protein kinase (Pask) is an evolutionarily conserved protein kinase implicated in energy homeostasis and metabolic regulation across eukaryotic species. We now describe an unexpected role of Pask in promoting the differentiation of myogenic progenitor cells, embryonic stem cell...

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Bibliographic Details
Main Authors: Chintan K Kikani, Xiaoying Wu, Litty Paul, Hana Sabic, Zuolian Shen, Arvind Shakya, Alexandra Keefe, Claudio Villanueva, Gabrielle Kardon, Barbara Graves, Dean Tantin, Jared Rutter
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-09-01
Series:eLife
Subjects:
PASK
WDR5
muscle differentiation
MyoD
myogenin
stem cells
Online Access:https://elifesciences.org/articles/17985

Internet

https://elifesciences.org/articles/17985

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