Exome-wide analysis of bi-allelic alterations identifies a Lynch phenotype in The Cancer Genome Atlas

Exome-wide analysis of bi-allelic alterations identifies a Lynch phenotype in The Cancer Genome Atlas

Abstract Background Cancer susceptibility germline variants generally require somatic alteration of the remaining allele to drive oncogenesis and, in some cases, tumor mutational profiles. Whether combined germline and somatic bi-allelic alterations are universally required for germline variation to...

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Bibliographic Details
Main Authors: Alexandra R. Buckley, Trey Ideker, Hannah Carter, Olivier Harismendy, Nicholas J. Schork
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Genome Medicine
Subjects:
Cancer genomics
Cancer germline
Cancer predisposition
TCGA
Microsatellite instability
Lynch syndrome
Online Access:http://link.springer.com/article/10.1186/s13073-018-0579-5

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http://link.springer.com/article/10.1186/s13073-018-0579-5

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