Prenatal Metformin Therapy Attenuates Hypertension of Developmental Origin in Male Adult Offspring Exposed to Maternal High-Fructose and Post-Weaning High-Fat Diets

Prenatal Metformin Therapy Attenuates Hypertension of Developmental Origin in Male Adult Offspring Exposed to Maternal High-Fructose and Post-Weaning High-Fat Diets

Widespread consumption of a Western diet, comprised of highly refined carbohydrates and fat, may play a role in the epidemic of hypertension. Hypertension can take origin from early life. Metformin is the preferred treatment for type 2 diabetes. We examined whether prenatal metformin therapy can pre...

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Bibliographic Details
Main Authors: You-Lin Tain, Kay L. H. Wu, Wei-Chia Lee, Steve Leu, Julie Y. H. Chan
Format: Article
Language:English
Published: MDPI AG 2018-04-01
Series:International Journal of Molecular Sciences
Subjects:
developmental origins of health and disease (DOHaD)
high-fat
fructose
hypertension
metformin
nitric oxide
nutrient sensing signal
oxidative stress
renin angiotensin system
Online Access:http://www.mdpi.com/1422-0067/19/4/1066

Internet

http://www.mdpi.com/1422-0067/19/4/1066

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