Proteomic analysis shows synthetic oleanane triterpenoid binds to mTOR.

New multifunctional drugs that target multiple disease-relevant networks offer a novel approach to the prevention and treatment of many diseases. New synthetic oleanane triterpenoids (SO), such as CDDO (2-cyano-3,12-dioxooleana-1,9-dien-28-oic acid) and its derivatives, are multifunctional compounds...

Full description

Bibliographic Details
Main Authors: Mark M Yore, Arminja N Kettenbach, Michael B Sporn, Scott A Gerber, Karen T Liby
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3144948?pdf=render