Jowiseungki decoction affects diabetic nephropathy in mice through renal injury inhibition as evidenced by network pharmacology and gut microbiota analyses

Jowiseungki decoction affects diabetic nephropathy in mice through renal injury inhibition as evidenced by network pharmacology and gut microbiota analyses

Abstract Background Jowiseungki decoction (JSD) is a prescription commonly used for the treatment of diabetic complications or diabetic nephropathy (DN) in traditional medicine clinics. However, the underlying therapeutic mechanisms of JSD are still unclear. Methods Streptozotocin (STZ)-induced DN m...

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Bibliographic Details
Main Authors: Xianglong Meng, Junnan Ma, Seok Yong Kang, Hyo Won Jung, Yong-Ki Park
Format: Article
Language:English
Published: BMC 2020-03-01
Series:Chinese Medicine
Subjects:
Diabetic nephropathy
Jowiseungki decoction (JSD)
Network pharmacology
Gut microbiota
PKCα/TGF-β1/Akt pathway
NF-κB/α-SMA pathway
Online Access:http://link.springer.com/article/10.1186/s13020-020-00306-0

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http://link.springer.com/article/10.1186/s13020-020-00306-0

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