A simple HPLC-fluorescence method for the measurement of R,S-sotalol in the plasma of patients with life-threatening cardiac arrhythmias

A simple HPLC-fluorescence method for the measurement of R,S-sotalol in the plasma of patients with life-threatening cardiac arrhythmias

R,S-sotalol, a ß-blocker drug with class III antiarrhythmic properties, is prescribed to patients with ventricular, atrial and supraventricular arrhythmias. A simple and sensitive method based on HPLC-fluorescence is described for the quantification of R,S-sotalol racemate in 500 µl of plasma. R,S-s...

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Bibliographic Details
Main Authors: S.R. Santos, O. Papini, C.E. Omosako, M.D. Pereira, T.B.G. Quintavalle, M.F. Riccio, A. Kurata, V.A. Pereira, G. Di-Pietro, O.E. Della-Paschoa, M. Danhof, P.L. Da-Luz
Format: Article
Language:English
Published: Associação Brasileira de Divulgação Científica 2000-02-01
Series:Brazilian Journal of Medical and Biological Research
Subjects:
R,S-sotalol racemate
HPLC analysis
fluorescence detection
pharmacokinetics
cardiac arrhythmias
high-risk patients
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000200006

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http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2000000200006

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