Expression of HLA-DR in Cytotoxic T Lymphocytes: A Validated Predictive Biomarker and a Potential Therapeutic Strategy in Breast Cancer

Expression of HLA-DR in Cytotoxic T Lymphocytes: A Validated Predictive Biomarker and a Potential Therapeutic Strategy in Breast Cancer

Neoadjuvant chemotherapy (NACT) is common in breast cancer (BC) treatment, though more than half of the patients lack an effective response. Therefore, new predictive biomarkers and alternative therapies are crucial. Previously, we proposed HLA-DR-expressing cytotoxic T lymphocytes (CTLs) as a poten...

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Bibliographic Details
Main Authors: Diana P. Saraiva, Sofia Azeredo-Lopes, Ana Antunes, Rute Salvador, Paula Borralho, Beatriz Assis, Isabel L. Pereira, Zita Seabra, Ida Negreiros, António Jacinto, Sofia Braga, M. Guadalupe Cabral
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Cancers
Subjects:
breast cancer
cytotoxic T lymphocytes
HLA-DR
biomarker
neoadjuvant chemotherapy
3D co-cultures
Online Access:https://www.mdpi.com/2072-6694/13/15/3841

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https://www.mdpi.com/2072-6694/13/15/3841

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