Cerebrospinal fluid levels of glial marker YKL-40 strongly associated with axonal injury in HIV infection

Cerebrospinal fluid levels of glial marker YKL-40 strongly associated with axonal injury in HIV infection

Abstract Background HIV-1 infects the central nervous system (CNS) shortly after transmission. This leads to a chronic intrathecal immune activation. YKL-40, a biomarker that mainly reflects activation of astroglial cells, has not been thoroughly investigated in relation to HIV. The objective of our...

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Bibliographic Details
Main Authors: Linn Hermansson, Aylin Yilmaz, Markus Axelsson, Kaj Blennow, Dietmar Fuchs, Lars Hagberg, Jan Lycke, Henrik Zetterberg, Magnus Gisslén
Format: Article
Language:English
Published: BMC 2019-01-01
Series:Journal of Neuroinflammation
Subjects:
HIV
Cerebrospinal fluid
YKL-40
Neurofilament protein
Online Access:http://link.springer.com/article/10.1186/s12974-019-1404-9

Internet

http://link.springer.com/article/10.1186/s12974-019-1404-9

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