Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8

Ezetimibe normalizes metabolic defects in mice lacking ABCG5 and ABCG8

The ATP binding cassette transporters ABCG5 (G5) and ABCG8 (G8) limit the accumulation of neutral sterols by restricting sterol uptake from the intestine and promoting sterol excretion into bile. Humans and mice lacking G5 and G8 (G5G8−/−) accumulate plant sterols in the blood and tissues. However,...

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Bibliographic Details
Main Authors: Liqing Yu, Klaus von Bergmann, Dieter Lütjohann, Helen H. Hobbs, Jonathan C. Cohen
Format: Article
Language:English
Published: Elsevier 2005-08-01
Series:Journal of Lipid Research
Subjects:
ATP binding cassette transporter G5
ATP binding cassette transporter G8
sitosterolemia
cholesterol
bile
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520329734

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http://www.sciencedirect.com/science/article/pii/S0022227520329734

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