Intravital imaging reveals synergistic effect of CAR T-cells and radiation therapy in a preclinical immunocompetent glioblastoma model

Intravital imaging reveals synergistic effect of CAR T-cells and radiation therapy in a preclinical immunocompetent glioblastoma model

Recent advances in novel immune strategies, particularly chimeric antigen receptor (CAR)-bearing T-cells, have shown limited efficacy against glioblastoma (GBM) in clinical trials. We currently have an incomplete understanding of how these emerging therapies integrate with the current standard of ca...

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Bibliographic Details
Main Authors: Surya Murty, Samuel T. Haile, Corinne Beinat, Amin Aalipour, Israt S. Alam, Tara Murty, Travis M. Shaffer, Chirag B. Patel, Edward E. Graves, Crystal L. Mackall, Sanjiv S. Gambhir
Format: Article
Language:English
Published: Taylor & Francis Group 2020-01-01
Series:OncoImmunology
Subjects:
chimeric antigen receptor (car)
glioblastoma
intravital microscopy
imaging
immunotherapy
Online Access:http://dx.doi.org/10.1080/2162402X.2020.1757360

Internet

http://dx.doi.org/10.1080/2162402X.2020.1757360

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