Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin

Mechanism of synergistic actin filament pointed end depolymerization by cyclase-associated protein and cofilin

The cofilin family proteins are actin disassembly factors but the disassembly mechanism is poorly understood. Here authors show that cyclase-associated-protein (CAP) works in synergy with cofilin to accelerate actin filament depolymerization by nearly 100-fold and reveal how CAP destabilizes the int...

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Bibliographic Details
Main Authors: Tommi Kotila, Hugo Wioland, Giray Enkavi, Konstantin Kogan, Ilpo Vattulainen, Antoine Jégou, Guillaume Romet-Lemonne, Pekka Lappalainen
Format: Article
Language:English
Published: Nature Publishing Group 2019-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-019-13213-2

Internet

https://doi.org/10.1038/s41467-019-13213-2

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