LncRNA BCAR4, targeting to miR-665/STAT3 signaling, maintains cancer stem cells stemness and promotes tumorigenicity in colorectal cancer

LncRNA BCAR4, targeting to miR-665/STAT3 signaling, maintains cancer stem cells stemness and promotes tumorigenicity in colorectal cancer

Abstract Background Breast cancer anti-estrogen resistance 4 (BCAR4) is closely associated with colorectal cancer (CRC) initiation and propagation. However, the mechanisms underlying BCAR4 function in colon cancer remains largely unknown. In this study, we hypothesized that BCAR4 could regulate colo...

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Bibliographic Details
Main Authors: Shurui Ouyang, Xin Zhou, Zhengquan Chen, Maijian Wang, Xinbin Zheng, Ming Xie
Format: Article
Language:English
Published: BMC 2019-03-01
Series:Cancer Cell International
Subjects:
Breast cancer anti-estrogen resistance 4 (BCAR4)
Colorectal cancer (CRC)
LncRNA
ALDH+ cancer stem/initiating cells
miR-665
Online Access:http://link.springer.com/article/10.1186/s12935-019-0784-3

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http://link.springer.com/article/10.1186/s12935-019-0784-3

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