Galectin-3 controls the response of microglial cells to limit cuprizone-induced demyelination

Galectin-3 controls the response of microglial cells to limit cuprizone-induced demyelination

Galectin-3 (Gal-3) is a β-galactoside-binding lectin that plays an important role in inflammatory and neurodegenerative diseases. Cuprizone (CPZ)-induced demyelination is characterized by the loss of mature oligodendrocytes (OLG) by apoptosis, myelin sheath degeneration and recruitment of microglia...

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Bibliographic Details
Main Authors: H.C. Hoyos, M. Rinaldi, S.P. Mendez-Huergo, M. Marder, G.A. Rabinovich, J.M. Pasquini, L.A. Pasquini
Format: Article
Language:English
Published: Elsevier 2014-02-01
Series:Neurobiology of Disease
Subjects:
Galectin-3
Demyelination
Cuprizone
Microglial phenotype
Oligodendroglial differentiation
TREM-2b
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996113002982

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http://www.sciencedirect.com/science/article/pii/S0969996113002982

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