Galectin-3 controls the response of microglial cells to limit cuprizone-induced demyelination
Galectin-3 (Gal-3) is a β-galactoside-binding lectin that plays an important role in inflammatory and neurodegenerative diseases. Cuprizone (CPZ)-induced demyelination is characterized by the loss of mature oligodendrocytes (OLG) by apoptosis, myelin sheath degeneration and recruitment of microglia...
Main Authors: | H.C. Hoyos, M. Rinaldi, S.P. Mendez-Huergo, M. Marder, G.A. Rabinovich, J.M. Pasquini, L.A. Pasquini |
---|---|
Format: | Article |
Language: | English |
Published: |
Elsevier
2014-02-01
|
Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996113002982 |
Similar Items
-
Age Influences Microglial Activation After Cuprizone-Induced Demyelination
by: Barbara Klein, et al.
Published: (2018-09-01) -
Galectin-1 circumvents lysolecithin-induced demyelination through the modulation of microglial polarization/phagocytosis and oligodendroglial differentiation
by: Mariana Rinaldi, et al.
Published: (2016-12-01) -
Delayed Demyelination and Impaired Remyelination in Aged Mice in the Cuprizone Model
by: Stefan Gingele, et al.
Published: (2020-04-01) -
Evaluation of neuroprotective effects of alpha-tocopherol in cuprizone-induced demyelination model of multiple sclerosis
by: Nilesh Kumar Mitra, et al.
Published: (2020-01-01) -
Voluntary running wheel attenuates motor deterioration and brain damage in cuprizone-induced demyelination
by: Georgia Mandolesi, et al.
Published: (2019-09-01)