MiRNA‐516a promotes bladder cancer metastasis by inhibiting MMP9 protein degradation via the AKT/FOXO3A/SMURF1 axis

MiRNA‐516a promotes bladder cancer metastasis by inhibiting MMP9 protein degradation via the AKT/FOXO3A/SMURF1 axis

Abstract Background Metastasis is the leading cause of death in patients with bladder cancer (BC). However, current available treatments exert little effects on metastatic BC. Moreover, traditional grading and staging have only a limited ability to identify metastatic BC. Accumulating evidence indic...

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Bibliographic Details
Main Authors: Yuanyuan Chang, Honglei Jin, Hongyan Li, Jiugao Ma, Zhijian Zheng, Binuo Sun, Yiting Lyu, Mengqi Lin, He Zhao, Liping Shen, Ruirui Zhang, Shuilian Wu, Weiwei Lin, Yongyong Lu, Qipeng Xie, Gang Zhang, Xing Huang, Haishan Huang
Format: Article
Language:English
Published: Wiley 2020-12-01
Series:Clinical and Translational Medicine
Subjects:
bladder cancer
metastasis
migration and invasion
miR‐516a
PHLPP2
Online Access:https://doi.org/10.1002/ctm2.263

Internet

https://doi.org/10.1002/ctm2.263

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