One-carbon metabolism, cognitive impairment and CSF measures of Alzheimer pathology: homocysteine and beyond

One-carbon metabolism, cognitive impairment and CSF measures of Alzheimer pathology: homocysteine and beyond

Abstract Background Hyperhomocysteinemia is a risk factor for cognitive decline and dementia, including Alzheimer disease (AD). Homocysteine (Hcy) is a sulfur-containing amino acid and metabolite of the methionine pathway. The interrelated methionine, purine, and thymidylate cycles constitute the on...

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Main Authors: Loïc Dayon, Seu Ping Guiraud, John Corthésy, Laeticia Da Silva, Eugenia Migliavacca, Domilė Tautvydaitė, Aikaterini Oikonomidi, Barbara Moullet, Hugues Henry, Sylviane Métairon, Julien Marquis, Patrick Descombes, Sebastiano Collino, François-Pierre J. Martin, Ivan Montoliu, Martin Kussmann, Jérôme Wojcik, Gene L. Bowman, Julius Popp
Format: Article
Language:English
Published: BMC 2017-06-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease
Cognition
CSF
Homocysteine
Metabolomics
One-carbon metabolism
Online Access:http://link.springer.com/article/10.1186/s13195-017-0270-x

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http://link.springer.com/article/10.1186/s13195-017-0270-x

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