A Novel Method Facilitating the Simple and Low-Cost Preparation of Human Osteochondral Slice Explants for Large-Scale Native Tissue Analysis

A Novel Method Facilitating the Simple and Low-Cost Preparation of Human Osteochondral Slice Explants for Large-Scale Native Tissue Analysis

For in vitro modeling of human joints, osteochondral explants represent an acceptable compromise between conventional cell culture and animal models. However, the scarcity of native human joint tissue poses a challenge for experiments requiring high numbers of samples and makes the method rather uns...

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Bibliographic Details
Main Authors: Jacob Spinnen, Lennard K. Shopperly, Carsten Rendenbach, Anja A. Kühl, Ufuk Sentürk, Daniel Kendoff, Shabnam Hemmati-Sadeghi, Michael Sittinger, Tilo Dehne
Format: Article
Language:English
Published: MDPI AG 2021-06-01
Series:International Journal of Molecular Sciences
Subjects:
osteoarthritis
osteochondral explant culture
joint modelling
pharmacological assay
native tissue analysis
Online Access:https://www.mdpi.com/1422-0067/22/12/6394

Internet

https://www.mdpi.com/1422-0067/22/12/6394

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