Type I IFN system activation in newborns exposed to Ro/SSA and La/SSB autoantibodies in utero

Type I IFN system activation in newborns exposed to Ro/SSA and La/SSB autoantibodies in utero

ObjectiveIn utero exposure of the fetus to Ro/La autoantibodies may lead to congenital heart block (CHB). In the mother, these autoantibodies are associated with activation of the type I interferon (IFN)-system. As maternal autoantibodies are transferred to the fetus during pregnancy, we investigate...

Full description

Bibliographic Details
Main Authors: Lars Rönnblom, Gunnar Bergman, Maija-Leena Eloranta, Malin Hedlund, Gudny Ella Thorlacius, Margarita Ivanchenko, Vijole Ottosson, Nikolaos Kyriakidis, Linda Lagnefeldt, Joanna Tingström, Allan Sirsjö, Emma Aronsson, Alexander Espinosa
Format: Article
Language:English
Published: BMJ Publishing Group 2020-05-01
Series:RMD Open
Online Access:https://rmdopen.bmj.com/content/6/1/e000989.full

Internet

https://rmdopen.bmj.com/content/6/1/e000989.full

Similar Items