A monomethyl auristatin E-conjugated antibody to guanylyl cyclase C is cytotoxic to target-expressing cells in vitro and in vivo.

A monomethyl auristatin E-conjugated antibody to guanylyl cyclase C is cytotoxic to target-expressing cells in vitro and in vivo.

Guanylyl cyclase C (GCC) is a cell-surface protein that is expressed by normal intestinal epithelial cells, more than 95% of metastatic colorectal cancers (mCRC), and the majority of gastric and pancreatic cancers. Due to strict apical localization, systemically delivered GCC-targeting agents should...

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Bibliographic Details
Main Authors: Melissa Gallery, Julie Zhang, Daniel P Bradley, Pamela Brauer, Donna Cvet, Jose Estevam, Hadi Danaee, Edward Greenfield, Ping Li, Mark Manfredi, Huay-Keng Loke, Claudia Rabino, Brad Stringer, Mark Williamson, Tim Wyant, Johnny Yang, Qing Zhu, Adnan Abu-Yousif, O Petter Veiby
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC5784926?pdf=render

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http://europepmc.org/articles/PMC5784926?pdf=render

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