Hedgehog proteins create a dynamic cholesterol interface.

Hedgehog proteins create a dynamic cholesterol interface.

During formation of the Hedgehog (Hh) signaling proteins, cooperative activities of the Hedgehog INTein (Hint) fold and Sterol Recognition Region (SRR) couple autoproteolysis to cholesterol ligation. The cholesteroylated Hh morphogens play essential roles in embryogenesis, tissue regeneration, and t...

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Bibliographic Details
Main Authors: Amirhossein Mafi, Rahul Purohit, Erika Vielmas, Alexa R Lauinger, Brandon Lam, Yu-Shiuan Cheng, Tianyi Zhang, Yiran Huang, Soo-Kyung Kim, William A Goddard, Alison E Ondrus
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2021-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0246814

Internet

https://doi.org/10.1371/journal.pone.0246814

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