Inhibitory Evaluation of Sulfonamide Chalcones on β-Secretase and Acylcholinesterase

Inhibitory Evaluation of Sulfonamide Chalcones on β-Secretase and Acylcholinesterase

The action of β-secretase (BACE1) is strongly correlated with the onset of Alzheimer’s disease (AD). Aminochalcone derivatives were examined for their ability to inhibit BACE1. Parent aminochalcones showed two digit micromolar IC50s against BACE1. Potency was enhanced 10-f...

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Bibliographic Details
Main Authors: Dae Wook Kim, Heung Joo Yuk, Hye Jin Kim, Jin Hyo Kim, Hyung Won Ryu, Marcus J. Curtis-Long, Jung Keun Cho, Jae Eun Kang, Ki Hun Park
Format: Article
Language:English
Published: MDPI AG 2012-12-01
Series:Molecules
Subjects:
sulfonamide chalcone
Alzheimer&#8217
s disease (AD)
&#946
-secretase
acetylcholinesterase (AChE)
butyrylcholinesterase (BChE)
mixed inhibition
Online Access:http://www.mdpi.com/1420-3049/18/1/140

Internet

http://www.mdpi.com/1420-3049/18/1/140

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