The nuclear lamina is a hub for the nuclear function of Jacob

The nuclear lamina is a hub for the nuclear function of Jacob

Abstract Jacob is a synapto-nuclear messenger protein that couples NMDAR activity to CREB-dependent gene expression. In this study, we investigated the nuclear distribution of Jacob and report a prominent targeting to the nuclear envelope that requires NMDAR activity and nuclear import. Immunogold e...

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Bibliographic Details
Main Authors: Sebastian Samer, Rajeev Raman, Gregor Laube, Michael R. Kreutz, Anna Karpova
Format: Article
Language:English
Published: BMC 2021-01-01
Series:Molecular Brain
Subjects:
Jacob/Nsmf
Lamin B1
CRM1
Nuclear export
NMDAR
Synapse-to-nucleus
Online Access:https://doi.org/10.1186/s13041-020-00722-1

Internet

https://doi.org/10.1186/s13041-020-00722-1

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