Molecular Crosstalk Between MYC and HIF in Cancer

The transcription factor c-MYC (MYC thereafter) is a global regulator of gene expression. It is overexpressed or deregulated in human cancers of diverse origins and plays a key role in the development of cancers. Hypoxia-inducible factors (HIFs), a central regulator for cells to adapt to low cellula...

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Bibliographic Details
Main Authors: Yanping Li, Xiao-Xin Sun, David Z. Qian, Mu-Shui Dai
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-11-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
MYC
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2020.590576/full