Augmentation of myocardial If dysregulates calcium homeostasis and causes adverse cardiac remodeling
The depolarizing funny current contributing to cardiac pacemaking is upregulated in the myocardium of failing and infarcted hearts, but whether the current is implied in disease mechanisms is unclear. Here the authors generate HCN4 transgenic mice and show that upregulation of funny current to the...
Main Authors: | , , , , , , , , , , , , , , , , |
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Format: | Article |
Language: | English |
Published: |
Nature Publishing Group
2019-07-01
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Series: | Nature Communications |
Online Access: | https://doi.org/10.1038/s41467-019-11261-2 |