Blocking Mammalian Target of Rapamycin (mTOR) Attenuates HIF-1α Pathways Engaged-Vascular Endothelial Growth Factor (VEGF) in Diabetic Retinopathy

Blocking Mammalian Target of Rapamycin (mTOR) Attenuates HIF-1α Pathways Engaged-Vascular Endothelial Growth Factor (VEGF) in Diabetic Retinopathy

Background/Aims: Prior studies demonstrate that hypoxia inducible factor subtype 1α (HIF-1α) in retinal tissues is involved in development of diabetic retinopathy (DR). In this report, we particularly examined the role played by mammalian target of rapamycin (mTOR) in regulating expression of HIF-1α...

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Bibliographic Details
Main Authors: Jie Wei, Hua Jiang, Hongrui Gao, Guangjie Wang
Format: Article
Language:English
Published: Cell Physiol Biochem Press GmbH & Co KG 2016-12-01
Series:Cellular Physiology and Biochemistry
Subjects:
HIF-1α
VEGF
Diabetic retinopathy
mTOR
Online Access:http://www.karger.com/Article/FullText/453207

Internet

http://www.karger.com/Article/FullText/453207

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