A Single Dose of Modified Vaccinia Ankara Expressing Lassa Virus-like Particles Protects Mice from Lethal Intra-cerebral Virus Challenge

A Single Dose of Modified Vaccinia Ankara Expressing Lassa Virus-like Particles Protects Mice from Lethal Intra-cerebral Virus Challenge

Lassa fever surpasses Ebola, Marburg, and all other hemorrhagic fevers except Dengue in its public health impact. Caused by Lassa virus (LASV), the disease is a scourge on populations in endemic areas of West Africa, where reported incidence is higher. Here, we report construction, characterization,...

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Bibliographic Details
Main Authors: Maria S. Salvato, Arban Domi, Camila Guzmán-Cardozo, Sandra Medina-Moreno, Juan Carlos Zapata, Haoting Hsu, Nathanael McCurley, Rahul Basu, Mary Hauser, Michael Hellerstein, Farshad Guirakhoo
Format: Article
Language:English
Published: MDPI AG 2019-08-01
Series:Pathogens
Subjects:
Lassa vaccine
replication-deficient MVA vector
VLP formation
single-dose efficacy
cell-mediated immunity
Online Access:https://www.mdpi.com/2076-0817/8/3/133

Internet

https://www.mdpi.com/2076-0817/8/3/133

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