ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer

Despite initial benefits in treating HER2-positive breast cancer patients with lapatinib, resistance is prevalent. Here the authors show that lapatinib resistance can be ascribed to mTOR-mediated re-activation of ERRα and to the consequent induction of a metabolic adaptation.

Bibliographic Details
Main Authors:	Geneviève Deblois, Harvey W. Smith, Ingrid S. Tam, Simon-Pierre Gravel, Maxime Caron, Paul Savage, David P. Labbé, Louis R. Bégin, Michel L. Tremblay, Morag Park, Guillaume Bourque, Julie St-Pierre, William J. Muller, Vincent Giguère
Format:	Article
Language:	English
Published:	Nature Publishing Group 2016-07-01
Series:	Nature Communications
Online Access:	https://doi.org/10.1038/ncomms12156

id	doaj-a807b71593d5451987bf6593688f61a3
record_format	Article
spelling	doaj-a807b71593d5451987bf6593688f61a32021-05-11T10:43:40ZengNature Publishing GroupNature Communications2041-17232016-07-017111410.1038/ncomms12156ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancerGeneviève Deblois0Harvey W. Smith1Ingrid S. Tam2Simon-Pierre Gravel3Maxime Caron4Paul Savage5David P. Labbé6Louis R. Bégin7Michel L. Tremblay8Morag Park9Guillaume Bourque10Julie St-Pierre11William J. Muller12Vincent Giguère13Goodman Cancer Research Centre, McGill UniversityGoodman Cancer Research Centre, McGill UniversityGoodman Cancer Research Centre, McGill UniversityGoodman Cancer Research Centre, McGill UniversityDepartment of Human Genetics, McGill UniversityGoodman Cancer Research Centre, McGill UniversityGoodman Cancer Research Centre, McGill UniversityService d’anatomopathologie, Hôpital du Sacré-Cœur de MontréalGoodman Cancer Research Centre, McGill UniversityGoodman Cancer Research Centre, McGill UniversityDepartment of Human Genetics, McGill UniversityGoodman Cancer Research Centre, McGill UniversityGoodman Cancer Research Centre, McGill UniversityGoodman Cancer Research Centre, McGill UniversityDespite initial benefits in treating HER2-positive breast cancer patients with lapatinib, resistance is prevalent. Here the authors show that lapatinib resistance can be ascribed to mTOR-mediated re-activation of ERRα and to the consequent induction of a metabolic adaptation.https://doi.org/10.1038/ncomms12156
collection	DOAJ
language	English
format	Article
sources	DOAJ
author	Geneviève Deblois Harvey W. Smith Ingrid S. Tam Simon-Pierre Gravel Maxime Caron Paul Savage David P. Labbé Louis R. Bégin Michel L. Tremblay Morag Park Guillaume Bourque Julie St-Pierre William J. Muller Vincent Giguère
spellingShingle	Geneviève Deblois Harvey W. Smith Ingrid S. Tam Simon-Pierre Gravel Maxime Caron Paul Savage David P. Labbé Louis R. Bégin Michel L. Tremblay Morag Park Guillaume Bourque Julie St-Pierre William J. Muller Vincent Giguère ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer Nature Communications
author_facet	Geneviève Deblois Harvey W. Smith Ingrid S. Tam Simon-Pierre Gravel Maxime Caron Paul Savage David P. Labbé Louis R. Bégin Michel L. Tremblay Morag Park Guillaume Bourque Julie St-Pierre William J. Muller Vincent Giguère
author_sort	Geneviève Deblois
title	ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer
title_short	ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer
title_full	ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer
title_fullStr	ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer
title_full_unstemmed	ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer
title_sort	errα mediates metabolic adaptations driving lapatinib resistance in breast cancer
publisher	Nature Publishing Group
series	Nature Communications
issn	2041-1723
publishDate	2016-07-01
description	Despite initial benefits in treating HER2-positive breast cancer patients with lapatinib, resistance is prevalent. Here the authors show that lapatinib resistance can be ascribed to mTOR-mediated re-activation of ERRα and to the consequent induction of a metabolic adaptation.
url	https://doi.org/10.1038/ncomms12156
work_keys_str_mv	AT genevievedeblois erramediatesmetabolicadaptationsdrivinglapatinibresistanceinbreastcancer AT harveywsmith erramediatesmetabolicadaptationsdrivinglapatinibresistanceinbreastcancer AT ingridstam erramediatesmetabolicadaptationsdrivinglapatinibresistanceinbreastcancer AT simonpierregravel erramediatesmetabolicadaptationsdrivinglapatinibresistanceinbreastcancer AT maximecaron erramediatesmetabolicadaptationsdrivinglapatinibresistanceinbreastcancer AT paulsavage erramediatesmetabolicadaptationsdrivinglapatinibresistanceinbreastcancer AT davidplabbe erramediatesmetabolicadaptationsdrivinglapatinibresistanceinbreastcancer AT louisrbegin erramediatesmetabolicadaptationsdrivinglapatinibresistanceinbreastcancer AT michelltremblay erramediatesmetabolicadaptationsdrivinglapatinibresistanceinbreastcancer AT moragpark erramediatesmetabolicadaptationsdrivinglapatinibresistanceinbreastcancer AT guillaumebourque erramediatesmetabolicadaptationsdrivinglapatinibresistanceinbreastcancer AT juliestpierre erramediatesmetabolicadaptationsdrivinglapatinibresistanceinbreastcancer AT williamjmuller erramediatesmetabolicadaptationsdrivinglapatinibresistanceinbreastcancer AT vincentgiguere erramediatesmetabolicadaptationsdrivinglapatinibresistanceinbreastcancer
_version_	1721447690572660736

ERRα mediates metabolic adaptations driving lapatinib resistance in breast cancer

Similar Items