Natalizumab promotes activation and pro-inflammatory differentiation of peripheral B cells in multiple sclerosis patients

Natalizumab promotes activation and pro-inflammatory differentiation of peripheral B cells in multiple sclerosis patients

Abstract Background In the past, multiple sclerosis (MS) medications have been primarily designed to modulate T cell properties. Based on the emerging concept that B cells are equally important for the propagation of MS, we compared the effect of four commonly used, primarily T cell-targeting MS med...

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Bibliographic Details
Main Authors: Jan W. Traub, Hannah L. Pellkofer, Katja Grondey, Ira Seeger, Christoph Rowold, Wolfgang Brück, Leila Husseini, Silke Häusser-Kinzel, Martin S. Weber
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Journal of Neuroinflammation
Subjects:
Multiple sclerosis
Natalizumab
B cells
Dimethyl fumarate
Glatiramer acetate
Fingolimod
Online Access:http://link.springer.com/article/10.1186/s12974-019-1593-2

Internet

http://link.springer.com/article/10.1186/s12974-019-1593-2

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