Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer

Targeting Pyruvate Kinase M2 and Lactate Dehydrogenase A Is an Effective Combination Strategy for the Treatment of Pancreatic Cancer

Reprogrammed glucose metabolism is one of the hallmarks of cancer, and increased expression of key glycolytic enzymes, such as pyruvate kinase M2 (PKM2) and lactate dehydrogenase A (LDHA), has been associated with poor prognosis in various malignancies. Targeting these enzymes could attenuate aerobi...

Full description

Bibliographic Details
Main Authors: Goran Hamid Mohammad, Vessela Vassileva, Pilar Acedo, Steven W. M. Olde Damink, Massimo Malago, Dipok Kumar Dhar, Stephen P. Pereira
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Cancers
Subjects:
pancreatic cancer
pyruvate kinase M2
lactate dehydrogenase A
glycolytic enzymes
combination therapy
Online Access:https://www.mdpi.com/2072-6694/11/9/1372

Internet

https://www.mdpi.com/2072-6694/11/9/1372

Similar Items