Spatiotemporal constraints on optogenetic inactivation in cortical circuits

Optogenetics allows manipulations of genetically and spatially defined neuronal populations with excellent temporal control. However, neurons are coupled with other neurons over multiple length scales, and the effects of localized manipulations thus spread beyond the targeted neurons. We benchmarked...

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Bibliographic Details
Main Authors: Nuo Li, Susu Chen, Zengcai V Guo, Han Chen, Yan Huo, Hidehiko K Inagaki, Guang Chen, Courtney Davis, David Hansel, Caiying Guo, Karel Svoboda
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-11-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/48622