Squalamine and Aminosterol Mimics Inhibit the Peptidoglycan Glycosyltransferase Activity of PBP1b

Peptidoglycan (PG) is an essential polymer of the bacterial cell wall and a major antibacterial target. Its synthesis requires glycosyltransferase (GTase) and transpeptidase enzymes that, respectively, catalyze glycan chain elongation and their cross-linking to form the protective sacculus of the ba...

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Bibliographic Details
Main Authors: Adrien Boes, Jean Michel Brunel, Adeline Derouaux, Frédéric Kerff, Ahmed Bouhss, Thierry Touze, Eefjan Breukink, Mohammed Terrak
Format: Article
Language:English
Published: MDPI AG 2020-07-01
Series:Antibiotics
Subjects:
Online Access:https://www.mdpi.com/2079-6382/9/7/373