Methylene Blue Mitigates Acute Neuroinflammation after Spinal Cord Injury through Inhibiting NLRP3 Inflammasome Activation in Microglia

Methylene Blue Mitigates Acute Neuroinflammation after Spinal Cord Injury through Inhibiting NLRP3 Inflammasome Activation in Microglia

The spinal cord injury (SCI) is a detrimental neurological disease involving the primary mechanical injury and secondary inflammatory damage. Curtailing the detrimental neuroinflammation would be beneficial for spinal cord function recovery. Microglia reside in the spinal cord and actively participa...

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Bibliographic Details
Main Authors: Zhi-Hang Lin, Si-Yuan Wang, Li-Li Chen, Jia-Yuan Zhuang, Qing-Feng Ke, Dan-Rui Xiao, Wen-Ping Lin
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-12-01
Series:Frontiers in Cellular Neuroscience
Subjects:
spinal cord injury
methylene blue
NLRP3
locomotor function
neuroinflammation
Online Access:http://journal.frontiersin.org/article/10.3389/fncel.2017.00391/full

Internet

http://journal.frontiersin.org/article/10.3389/fncel.2017.00391/full

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