Highly versatile cancer photoimmunotherapy using photosensitizer-conjugated avidin and biotin-conjugated targeting antibodies

Highly versatile cancer photoimmunotherapy using photosensitizer-conjugated avidin and biotin-conjugated targeting antibodies

Abstract Background Photoimmunotherapy (PIT) employing antibody-photosensitizer conjugates is a promising treatment for cancer. However, the fixed antigen specificity severely limits the efficacy and the applicability. Here we describe a universal strategy for PIT of cancer by using a near-infrared...

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Bibliographic Details
Main Authors: Naoto Shirasu, Hirotomo Shibaguchi, Hiromi Yamada, Masahide Kuroki, Shin’ichiro Yasunaga
Format: Article
Language:English
Published: BMC 2019-11-01
Series:Cancer Cell International
Subjects:
Avidin
Biotinylated antibody
Cancer stem cell
Tumor microenvironment
Photoimmunotherapy
Online Access:http://link.springer.com/article/10.1186/s12935-019-1034-4

Internet

http://link.springer.com/article/10.1186/s12935-019-1034-4

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