Aberrant Plasma Cell Contamination of Peripheral Blood Stem Cell Autografts, Assessed by Next-Generation Flow Cytometry, Is a Negative Predictor for Deep Response Post Autologous Transplantation in Multiple Myeloma; A Prospective Study in 199 Patients

Aberrant Plasma Cell Contamination of Peripheral Blood Stem Cell Autografts, Assessed by Next-Generation Flow Cytometry, Is a Negative Predictor for Deep Response Post Autologous Transplantation in Multiple Myeloma; A Prospective Study in 199 Patients

High-dose chemotherapy with autologous stem cell support (ASCT) is the standard of care for eligible newly diagnosed Multiple Myeloma (MM) patients. Stem cell graft contamination by aberrant plasma cells (APCs) has been considered a possible predictive marker of subsequent clinical outcome, but the...

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Bibliographic Details
Main Authors: Ioannis V. Kostopoulos, Evangelos Eleutherakis-Papaiakovou, Pantelis Rousakis, Ioannis Ntanasis-Stathopoulos, Chrysanthi Panteli, Nikolaos Orologas-Stavrou, Nikolaos Kanellias, Panagiotis Malandrakis, Christine-Ivy Liacos, Nikos E. Papaioannou, Aristea-Maria Papanota, Magdalini Migkou, Despina Fotiou, Maria Gavriatopoulou, Nikolaos V. Angelis, Efstathios Kastritis, Meletios-Athanasios Dimopoulos, Ourania E. Tsitsilonis, Evangelos Terpos
Format: Article
Language:English
Published: MDPI AG 2021-08-01
Series:Cancers
Subjects:
Multiple Myeloma
autologous stem cell transplantation
stem cell grafts
minimal residual disease
next-generation flow cytometry
tumor microenvironment
Online Access:https://www.mdpi.com/2072-6694/13/16/4047

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https://www.mdpi.com/2072-6694/13/16/4047

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