Structural Divergence in O-GlcNAc Glycans Displayed on Epidermal Growth Factor-like Repeats of Mammalian Notch1

Structural Divergence in O-GlcNAc Glycans Displayed on Epidermal Growth Factor-like Repeats of Mammalian Notch1

Extracellular O-GlcNAc is a novel class of modification catalyzed by epidermal growth factor-like (EGF)-domain specific O-GlcNAc transferase (EOGT). In mammals, EOGT is required for ligand-mediated Notch signaling for vascular development. Previous studies have revealed that O-GlcNAc in mammalian cu...

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Bibliographic Details
Main Authors: Mitsutaka Ogawa, Yuya Senoo, Kazutaka Ikeda, Hideyuki Takeuchi, Tetsuya Okajima
Format: Article
Language:English
Published: MDPI AG 2018-07-01
Series:Molecules
Subjects:
O-GlcNAc
Notch1
EOGT
EGF domain
O-GlcNAc glycan
Online Access:http://www.mdpi.com/1420-3049/23/7/1745

Internet

http://www.mdpi.com/1420-3049/23/7/1745

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