Knockdown of PTGS2 by CRISPR/CAS9 System Designates a New Potential Gene Target for Melanoma Treatment

Knockdown of PTGS2 by CRISPR/CAS9 System Designates a New Potential Gene Target for Melanoma Treatment

CRISPR/Cas9 has become a powerful method to engineer genomes and to activate or to repress genes expression. As such, in cancer research CRISPR/Cas9 technology represents an efficient tool to dissect mechanisms of tumorigenesis and to discover novel targets for drug development. Here, we employed th...

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Bibliographic Details
Main Authors: Giuseppe Ercolano, Paola De Cicco, Valentina Rubino, Giuseppe Terrazzano, Giuseppina Ruggiero, Roberta Carriero, Paolo Kunderfranco, Angela Ianaro
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-12-01
Series:Frontiers in Pharmacology
Subjects:
CRISPR/CAS9
PTGS2
COX2
melanoma
cancer
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2019.01456/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2019.01456/full

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