Structure-based characterization of novel TRPV5 inhibitors

Structure-based characterization of novel TRPV5 inhibitors

Transient receptor potential vanilloid 5 (TRPV5) is a highly calcium selective ion channel that acts as the rate-limiting step of calcium reabsorption in the kidney. The lack of potent, specific modulators of TRPV5 has limited the ability to probe the contribution of TRPV5 in disease phenotypes such...

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Bibliographic Details
Main Authors: Taylor ET Hughes, John Smith Del Rosario, Abhijeet Kapoor, Aysenur Torun Yazici, Yevgen Yudin, Edwin C Fluck III, Marta Filizola, Tibor Rohacs, Vera Y Moiseenkova-Bell
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2019-10-01
Series:eLife
Subjects:
TRP channel
TRPV5
Cryo-EM
ion channal
inhibitors
structure-based virtual screening
Online Access:https://elifesciences.org/articles/49572

Internet

https://elifesciences.org/articles/49572

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