Delayed goblet cell hyperplasia, acetylcholine receptor expression, and worm expulsion in SMC-specific IL-4Ralpha-deficient mice.

Delayed goblet cell hyperplasia, acetylcholine receptor expression, and worm expulsion in SMC-specific IL-4Ralpha-deficient mice.

Interleukin 4 receptor alpha (IL-4Ralpha) is essential for effective clearance of gastrointestinal nematode infections. Smooth muscle cells are considered to play a role in the type 2 immune response-driven expulsion of gastrointestinal nematodes. Previous studies have shown in vitro that signal tra...

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Bibliographic Details
Main Authors: William G C Horsnell, Antony J Cutler, J Claire Hoving, Helen Mearns, Elmarie Myburgh, Berenice Arendse, Fred D Finkelman, Gary K Owens, Dave Erle, Frank Brombacher
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2007-01-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.0030001

Internet

https://doi.org/10.1371/journal.ppat.0030001

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