Sensitivity of Rodent Microglia to Kynurenines in Models of Epilepsy and Inflammation In Vivo and In Vitro: Microglia Activation is Inhibited by Kynurenic Acid and the Synthetic Analogue SZR104

Sensitivity of Rodent Microglia to Kynurenines in Models of Epilepsy and Inflammation In Vivo and In Vitro: Microglia Activation is Inhibited by Kynurenic Acid and the Synthetic Analogue SZR104

Kynurenic acid is an endogenous modulator of ionotropic glutamate receptors and a suppressor of the immune system. Since glutamate and microglia are important in the pathogenesis of epilepsy, we investigated the possible action of the synthetic kynurenic acid analogue, SZR104, in epileptic mice and...

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Bibliographic Details
Main Authors: Noémi Lajkó, Diana Kata, Melinda Szabó, Adrienne Mátyás, Karolina Dulka, Imre Földesi, Ferenc Fülöp, Karoly Gulya, László Vécsei, András Mihály
Format: Article
Language:English
Published: MDPI AG 2020-12-01
Series:International Journal of Molecular Sciences
Subjects:
epilepsy
inflammation
kynurenic acid
lipopolysaccharide
microglia
pilocarpine
Online Access:https://www.mdpi.com/1422-0067/21/23/9333

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https://www.mdpi.com/1422-0067/21/23/9333

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