Astrocytic YAP prevents the demyelination through promoting expression of cholesterol synthesis genes in experimental autoimmune encephalomyelitis

Astrocytic YAP prevents the demyelination through promoting expression of cholesterol synthesis genes in experimental autoimmune encephalomyelitis

Abstract Cholesterols are the main components of myelin, and are mainly synthesized in astrocytes and transported to oligodendrocytes and neurons in the adult brain. It has been reported that Hippo/yes-associated protein (YAP) pathways are involved in cholesterol synthesis in the liver, however, it...

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Bibliographic Details
Main Authors: Jingjing Zhang, Xingxing Xu, Huitao Liu, Lingting Jin, Xiya Shen, Changnan Xie, Weiwei Xiang, Danlu Yang, Wenjin Feng, Jiaojiao Wang, Mianxian Wang, Tianyingying Dong, Haoyu Qiu, Lihao Wu, Ying Wang, Xu Zhang, Zhihui Huang
Format: Article
Language:English
Published: Nature Publishing Group 2021-10-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-021-04203-8

Internet

https://doi.org/10.1038/s41419-021-04203-8

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