Hepatitis B virus and site-specific nucleases: effects of genetic modifications in CRISPR/Cas9 on antiviral activity

Hepatitis B virus and site-specific nucleases: effects of genetic modifications in CRISPR/Cas9 on antiviral activity

Chronic hepatitis B is a severe liver disease caused by persistent infection of hepatitis B virus in human hepatocytes. Chronic hepatitis B is one of the most common diseases in the world. According to recent estimations, more than 250 million people are chronically infected and more than 1 million...

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Bibliographic Details
Main Authors: A. P. Kostyusheva, S. A. Brezgin, D. N. Zarifyan, D. S. Chistyakov, V. I. Gegechkory, E O. Bayurova, E. A. Volchkova, D. S. Kostyushev, V. P. Chulanov
Format: Article
Language:Russian
Published: Sankt-Peterburg : NIIÈM imeni Pastera 2019-07-01
Series:Infekciâ i Immunitet
Subjects:
hepatitis b virus
circular covalently closed dna
crispr/cas9
specificity
off-target effects
efficiency
modified grnas
Online Access:https://www.iimmun.ru/iimm/article/view/749

Internet

https://www.iimmun.ru/iimm/article/view/749

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