Antifibrotic effect of lung-resident progenitor cells with high aldehyde dehydrogenase activity

Antifibrotic effect of lung-resident progenitor cells with high aldehyde dehydrogenase activity

Abstract Background Aldehyde dehydrogenase (ALDH) is highly expressed in stem/progenitor cells in various tissues, and cell populations with high ALDH activity (ALDHbr) are associated with tissue repair. However, little is known about lung-resident ALDHbr. This study was performed to clarify the cha...

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Main Authors: Hiroshi Takahashi, Taku Nakashima, Takeshi Masuda, Masashi Namba, Shinjiro Sakamoto, Kakuhiro Yamaguchi, Yasushi Horimasu, Shintaro Miyamoto, Hiroshi Iwamoto, Kazunori Fujitaka, Hironobu Hamada, Noboru Hattori
Format: Article
Language:English
Published: BMC 2021-08-01
Series:Stem Cell Research & Therapy
Subjects:
Aldehyde dehydrogenase
Bleomycin
Cell therapy
Profibrotic cytokines
Pulmonary fibrosis
Stem cells
Online Access:https://doi.org/10.1186/s13287-021-02549-6

Internet

https://doi.org/10.1186/s13287-021-02549-6

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