Reductions of Circulating Nitric Oxide are Followed by Hypertension during Pregnancy and Increased Activity of Matrix Metalloproteinases-2 and -9 in Rats

Hypertensive pregnancy has been associated with reduced nitric oxide (NO), bioavailability, and increased activity of matrix metalloproteinases (MMPs). However, it is unclear if MMPs activation is regulated by NO during pregnancy. To this end, we examined activity of MMP-2 and MMP-9 in plasma, place...

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Bibliographic Details
Main Authors: Regina A. Nascimento, Jose S. Possomato-Vieira, Giselle F. Bonacio, Elen Rizzi, Carlos A. Dias-Junior
Format: Article
Language:English
Published: MDPI AG 2019-11-01
Series:Cells
Subjects:
Online Access:https://www.mdpi.com/2073-4409/8/11/1402