DNA polymerase [gamma] and disease: what we have learned from yeast

DNA polymerase [gamma] and disease: what we have learned from yeast

Mip1 is the Saccharomyces cerevisiae DNA polymerase [gamma] (Pol [gamma]), which is responsible for the replication of mitochondrial DNA (mtDNA). It belongs to the family A of the DNA polymerases and it is orthologous to human POLGA. In humans, mutations in POLG(1) cause many mitochondrial pathologi...

Full description

Bibliographic Details
Main Authors: Tiziana eLodi, Cristina eDallabona, Cecilia eNolli, Paola eGoffrini, Claudia eDonnini, Enrico eBaruffini
Format: Article
Language:English
Published: Frontiers Media S.A. 2015-03-01
Series:Frontiers in Genetics
Subjects:
yeast model
Mip1
DNA polymerase γ
Mip1 interactions
Pol γ mutations
Online Access:http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00106/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fgene.2015.00106/full

Similar Items